Structure of PDB 6a4b Chain F

Receptor sequence
>6a4bF (length=217) Species: 10090 (Mus musculus) [Search protein sequence]
PRAETFVFLDLEATGLPNMDPEIAEISLFAVHRSSLENPERDDSGSLVLP
RVLDKLTLCMCPERPFTAKASEITGLSSESLMHCGKAGFNGAVVRTLQGF
LSRQEGPICLVAHNGFDYDFPLLCTELQRLGAHLPQDTVCLDTLPALRGL
DRAHSHRKSYSLASLFHRYFQAEPSAASAEGDVHTLLLIFLHRAPELLAW
ADEQARSWAHIEPMYVP
3D structure
PDB6a4b Structural insights into the duplex DNA processing of TREX2
ChainF
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna F E16 G19 L20 I77 N118 D121 Y122 R167 S169 Y170 S171 L172 E12 G15 L16 I73 N114 D117 Y118 R157 S159 Y160 S161 L162
BS02 MG F D14 E16 D193 D10 E12 D182
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0008296 3'-5'-DNA exonuclease activity
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:6a4b, PDBe:6a4b, PDBj:6a4b
PDBsum6a4b
PubMed30357414
UniProtQ9R1A9|TREX2_MOUSE Three prime repair exonuclease 2 (Gene Name=Trex2)

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