Structure of PDB 5zgc Chain F

Receptor sequence
>5zgcF (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDPFFTLAKELYPGNY
KPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFDIR
ADVMADPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTE
AVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEE
MRDLVQRETGKL
3D structure
PDB5zgc Crystal Structure of SIRT3 in complex with H4K16bhb peptide
ChainF
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P155 D156 N229 D231 H248
Catalytic site (residue number reindexed from 1) P35 D36 N75 D77 H94
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F F294 G295 E296 V324 E325 P326 F112 G113 E114 V142 E143 P144
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5zgc, PDBe:5zgc, PDBj:5zgc
PDBsum5zgc
PubMed
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

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