Structure of PDB 5z79 Chain F

Receptor sequence
>5z79F (length=566) Species: 5855 (Plasmodium vivax) [Search protein sequence]
PRNIAVLNFGTNDKKNCVTILETALYLTEKYLGKIINSSYIYETVPEYPR
DISWIGDLIPTVENSRYEESEDLIYECKELEVFLKNEKINESIIREVSVE
DYENEARRIIKRNDEIMKKNLYTSYFFNLTVVVRTFVEDPLAMLVILKYI
EQIMKRMIDIDILFFNNYTIFEKSISLKGEDIYKIITKYIHINHTNRLDI
IQNLGDKIEFLCIPHVYTKYRYSILLCLNDIIPEYKHSTFEEAIRSTYNS
YVESFEEKYHINIRKNNKRLYVLKDKVSYLKERTHIVGILNVNYDSFSDG
GLFVDPVKAVERMFEMASDGASVIDIGGESSAPYVVPNPSVTERDLVMPV
LKLFKEEWHKLECEVGGGLQGKLQKVRDAKPIISIDTVNYDLFKECVEGE
LVDILNDISACTHNPEIIKLLRRKNKFYSVVLMHKRGNPHTMDKLTNYDD
LISDIKRYLEDRLHFLVLNGVPRYRVLFDVGLGFAKKHDQSIKLLQHIHV
YDEYPLFLGYSRKRFIVHCMQLLYQKNICGGLAIASYSFYKKVDLIRVHD
VLETKAVLDVLTRIHQ
3D structure
PDB5z79 Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase fromPlasmodium vivaxsheds light on drug resistance
ChainF
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HH2 F I340 N342 S347 F348 S381 D454 M501 D547 F552 G577 K581 R697 H699 I289 N291 S296 F297 S330 D386 M433 D479 F484 G509 K513 R547 H549
BS02 PAB F S382 A383 P384 F552 K581 R582 S331 A332 P333 F484 K513 R514
Gene Ontology
Molecular Function
GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156 dihydropteroate synthase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0016310 phosphorylation
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046656 folic acid biosynthetic process
Cellular Component
GO:0005740 mitochondrial envelope

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5z79, PDBe:5z79, PDBj:5z79
PDBsum5z79
PubMed30104413
UniProtA5JZS1

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