Structure of PDB 5yhw Chain F

Receptor sequence

>5yhwF (length=453) Species: 9823 (Sus scrofa) [Search protein sequence]

TVKVINDPIHGHIELHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVRELSEKQPELQISERDMLCVQIAGLCRNLGHGPF
SHMFDGRFIPLARPDVKWTHEQGSVNMFEHLVNSNGLIDVMEHYGLIPEE
DIWFIKEQITGWPYKGRPKEKSFLYEIVANKRNGIDVDKWDYFARDCHHL
GIQNNFDYKRFIKFARVCEVDNKKHICTREKEVGNLYDMFHTRNCLHRRA
YQHKVGNIIDTMITDAFLKADPYIEITGSEGKKYRISTAIDDMEAFTKLT
DNIFLEILYSTDPKLDAARAILKKIECRNLYKFVGETQPKIKRENYESLP
KGVASALKAEDFIVDVINMDYGMEDKNPIDNVRFYCKSDPNKAIIITKNQ
VSQLLPERFAEQLIRVYCKKTDEKSLFAARQHFVQWCLDNDFTKPQDGDV
VAP

3D structure

PDB

5yhw Structural characterization and directed modification of Sus scrofa SAMHD1 reveal the mechanism underlying deoxynucleotide regulation.

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DGT	F	K116 I118 I136 D137 R145	K3 I5 I23 D24 R32
BS02	DGT	F	Y155 V156 R451	Y42 V43 R328
BS03	DGT	F	V156 F157 I325 R372 H376 K377	V43 F44 I202 R249 H253 K254
BS04	DGT	F	R333 R352 K354 N358	R210 R229 K231 N235
BS05	DGT	F	L150 R164 R206 H215 H233 K312 Y315 D319 R366 Y374 Q375	L37 R51 R93 H102 H120 K189 Y192 D196 R243 Y251 Q252
BS06	DGT	F	V117 N119 H125	V4 N6 H12

External links

PDB	RCSB:5yhw, PDBe:5yhw, PDBj:5yhw
PDBsum	5yhw
PubMed	31152619
UniProt	I3LG77

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