Structure of PDB 5tuo Chain F

Receptor sequence
>5tuoF (length=199) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
WDYENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQADLQFKYAASKP
KAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKLSAHF
VHKDAKGRLLVLAIGFENPNLDPILEGIQKEVALDAFLPKSINYYHFNGS
LTAPPCTEGVAWFVIVSAKQLAEIKKRMPNQRPVQPDYNTVIIKSSAET
3D structure
PDB5tuo Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase.
ChainF
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H85 H110 H112 E116 H129 T191
Catalytic site (residue number reindexed from 1) H58 H83 H85 E89 H99 T152
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F H110 H112 H129 H83 H85 H99
BS02 1SA F H110 H129 L190 T191 H83 H99 L151 T152 MOAD: Ki=323nM
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5tuo, PDBe:5tuo, PDBj:5tuo
PDBsum5tuo
PubMed28002963
UniProtA0A0M3KL20

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