Structure of PDB 5tt8 Chain F

Receptor sequence
>5tt8F (length=216) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
WDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDLQFKYAAS
KPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRP
LSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDA
FLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKKRMKNSPNQRPV
QPDYNTVIIKSSAETR
3D structure
PDB5tt8 Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase.
ChainF
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H85 H110 H112 E116 H129 T191
Catalytic site (residue number reindexed from 1) H60 H85 H87 E91 H104 T166
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F H110 H112 H129 H85 H87 H104
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5tt8, PDBe:5tt8, PDBj:5tt8
PDBsum5tt8
PubMed28002963
UniProtA0A0M3KL20

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