Structure of PDB 5trl Chain F

Receptor sequence
>5trlF (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]
IIEFHVIGNSANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTL
ALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEY
HIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLM
ECELNPRIPYT
3D structure
PDB5trl KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase.
ChainF
Resolution2.299 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F568 F573 E575 I576 V577 C579 L611 I642 Y645
Catalytic site (residue number reindexed from 1) F67 F72 E74 I75 V76 C78 L110 I141 Y144
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SCA F Q530 L531 V577 F578 C579 A580 V581 Q586 V587 G589 G591 T592 Y617 A618 G620 Y621 K624 Q29 L30 V76 F77 C78 A79 V80 Q85 V86 G88 G90 T91 Y116 A117 G119 Y120 K123
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:5trl, PDBe:5trl, PDBj:5trl
PDBsum5trl
PubMed29211711
UniProtQ92830|KAT2A_HUMAN Histone acetyltransferase KAT2A (Gene Name=KAT2A)

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