Structure of PDB 5thp Chain F

Receptor sequence

>5thpF (length=193) Species: 9606 (Homo sapiens) [Search protein sequence]

LIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPR
VVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGR
RSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALD
TKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIFSI

3D structure

PDB

5thp Dramatic and concerted conformational changes enable rhodocetin to block alpha 2 beta 1 integrin selectively.

Chain

Resolution

3.006 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	F	S182 S184 D283	S11 S13 D112

External links

PDB	RCSB:5thp, PDBe:5thp, PDBj:5thp
PDBsum	5thp
PubMed	28704364
UniProt	P17301\|ITA2_HUMAN Integrin alpha-2 (Gene Name=ITGA2)

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