Structure of PDB 5t0i Chain F

Receptor sequence
>5t0iF (length=366) Species: 9606 (Homo sapiens) [Search protein sequence]
THELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDSQRKGKCAV
IKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVK
AMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGV
LMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFA
LAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPN
TQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKM
NVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEG
ILEVQAKKKANLQYYA
3D structure
PDB5t0i Structural basis for dynamic regulation of the human 26S proteasome.
ChainF
Resolution8.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP F D318 A341 R344 R347 D245 A268 R271 R274
BS02 ATP F G230 T231 G232 K233 T234 L235 D286 N333 H369 G393 A394 K397 G157 T158 G159 K160 T161 L162 D213 N260 H296 G320 A321 K324
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
GO:0042802 identical protein binding
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043921 modulation by host of viral transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0000932 P-body
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex
GO:0034774 secretory granule lumen
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5t0i, PDBe:5t0i, PDBj:5t0i
PDBsum5t0i
PubMed27791164
UniProtP17980|PRS6A_HUMAN 26S proteasome regulatory subunit 6A (Gene Name=PSMC3)

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