Structure of PDB 5ocw Chain F

Receptor sequence

>5ocwF (length=399) Species: 83332 (Mycobacterium tuberculosis H37Rv)

TSHDPDSGGHFGGPSGWGGRYVPEALMAVIEEVTAAYQKERVSQDFLDDL
DRLQANYAGRPSPLYEATRLSQHAGSARIFLKREDLNHTGSHKINNVLGQ
ALLARRMGKTRVIAETGAGQHGVATATACALLGLDCVIYMGGIDTARQAL
NVARMRLLGAEVVAVQTGSKTLKDAINEAFRDWVANADNTYYCFGTAAGP
HPFPTMVRDFQRIIGMEARVQIQGQAGRLPDAVVACVGGGSNAIGIFHAF
LDDPGVRLVGFEAAGDGVETGRHAATFTAGSPGAFHGSFSYLLQDEDGQT
IESHSISAGLDYPGVGPEHAWLKEAGRVDYRPITDSEAMDAFGLLCRMEG
IIPAIESAHAVAGALKLGVELGRGAVIVVNLSGRGDKDVETAAKWFGLL

3D structure

• PDB: 5ocw Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.
• Chain: F
• Resolution: 4.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K101 E123 S390
• Catalytic site (residue number reindexed from 1): K93 E115 S382
• Enzyme Commision number: 4.2.1.20: tryptophan synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	P1T	F	H100 K101 T124 G125 A126 Q128 H129 T204 G246 G248 S249 N250 G317 E364 S390 G391	H92 K93 T116 G117 A118 Q120 H121 T196 G238 G240 S241 N242 G309 E356 S382 G383

Gene Ontology

Molecular Function

• GO:0004834 tryptophan synthase activity
• GO:0016829 lyase activity

Biological Process

• GO:0000162 tryptophan biosynthetic process
• GO:0006568 tryptophan metabolic process
• GO:1901605 alpha-amino acid metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5ocw, PDBe:5ocw, PDBj:5ocw
• PDBsum: 5ocw
• PubMed: 28842600
• UniProt: P9WFX9|TRPB_MYCTU Tryptophan synthase beta chain (Gene Name=trpB)