Structure of PDB 5lqw Chain F

Receptor sequence
>5lqwF (length=218) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SAKVQVKESELPSSIPAQTGLTFNIWYNKWSQGFAGNTRFVSPFALQPQL
HSGKTRGDNDGQLFFCLFFAKGMCCLGPKCEYLHHIPDEEDCFGREKFAD
YREDMGGIGSFRKKNKTLYVGGIDGAAQIESRIRFVFSRLGDIDRIRYVE
SKNCGFVKFKYQANAEFAKEAMSNQTLLLPSDKEWDDRREGTGLLVKDPD
PAAQKRLQEELKLESLNM
3D structure
PDB5lqw Molecular architecture of the Saccharomyces cerevisiae activated spliceosome
ChainF
Resolution5.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna F P19 S20 G40 R46 F72 C73 F76 A77 N201 W212 P12 S13 G33 R39 F65 C66 F69 A70 N174 W185
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017070 U6 snRNA binding
GO:0036002 pre-mRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000387 spliceosomal snRNP assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0033120 positive regulation of RNA splicing
GO:0045292 mRNA cis splicing, via spliceosome
GO:0045787 positive regulation of cell cycle
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lqw, PDBe:5lqw, PDBj:5lqw
PDBsum5lqw
PubMed27562955
UniProtQ12046|CWC2_YEAST Pre-mRNA-splicing factor CWC2 (Gene Name=CWC2)

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