Structure of PDB 5kqv Chain F

Receptor sequence
>5kqvF (length=592) Species: 9606 (Homo sapiens) [Search protein sequence]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKD
DNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHG
CTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQD
WRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLL
CTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNL
AAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSF
YALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTNG
DQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ
NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYA
IFVKTLVTFSDERRTYGAKSDIIYVQTDATTFEDYLHNVVFV
3D structure
PDB5kqv How insulin engages its primary binding site on the insulin receptor.
ChainF
Resolution4.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F F39 K40 F39 K40
BS02 FUC F Q513 N514 Q500 N501
External links
PDB RCSB:5kqv, PDBe:5kqv, PDBj:5kqv
PDBsum5kqv
PubMed23302862
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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