Structure of PDB 5irc Chain F
Receptor sequence
>5ircF (length=170) Species:
9606
(Homo sapiens) [
Search protein sequence
]
IRKKLVIVGDGACGKTCLLIVNVYVPTVFENYVADIEVDGKQVELALWDT
AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNV
PIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECS
AKTKDGVREVFEMATRAALQ
3D structure
PDB
5irc
Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.
Chain
F
Resolution
1.72 Å
3D
structure
[
Spin on
]
[
Spin off
]
[
Reset orientation
]
[
High quality
]
[
Low quality
]
[
White background
]
[
Black background
]
[
Download
]
[
Download structure with residue number starting from 1
]
Enzymatic activity
Enzyme Commision number
3.6.5.2
: small monomeric GTPase.
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
GDP
F
A15 G17 K18 T19 C20 Y34 K118 D120 L121 S160 A161 K162
A12 G14 K15 T16 C17 Y24 K108 D110 L111 S150 A151 K152
BS02
MG
F
T19 T37
T16 T27
BS03
MGF
F
K18 T37 G62
K15 T27 G52
Gene Ontology
Molecular Function
GO:0003924
GTPase activity
GO:0003925
G protein activity
GO:0005515
protein binding
GO:0005525
GTP binding
GO:0016787
hydrolase activity
GO:0017022
myosin binding
GO:0019901
protein kinase binding
Biological Process
GO:0000902
cell morphogenesis
GO:0001764
neuron migration
GO:0001822
kidney development
GO:0001998
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0002363
alpha-beta T cell lineage commitment
GO:0003100
regulation of systemic arterial blood pressure by endothelin
GO:0003189
aortic valve formation
GO:0006357
regulation of transcription by RNA polymerase II
GO:0007010
cytoskeleton organization
GO:0007155
cell adhesion
GO:0007160
cell-matrix adhesion
GO:0007264
small GTPase-mediated signal transduction
GO:0007266
Rho protein signal transduction
GO:0007519
skeletal muscle tissue development
GO:0010812
negative regulation of cell-substrate adhesion
GO:0010975
regulation of neuron projection development
GO:0016477
cell migration
GO:0021762
substantia nigra development
GO:0021795
cerebral cortex cell migration
GO:0021861
forebrain radial glial cell differentiation
GO:0030036
actin cytoskeleton organization
GO:0030154
cell differentiation
GO:0030334
regulation of cell migration
GO:0030521
androgen receptor signaling pathway
GO:0031122
cytoplasmic microtubule organization
GO:0032467
positive regulation of cytokinesis
GO:0032956
regulation of actin cytoskeleton organization
GO:0033144
negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033688
regulation of osteoblast proliferation
GO:0034329
cell junction assembly
GO:0034446
substrate adhesion-dependent cell spreading
GO:0035385
Roundabout signaling pathway
GO:0036089
cleavage furrow formation
GO:0038027
apolipoprotein A-I-mediated signaling pathway
GO:0042476
odontogenesis
GO:0043123
positive regulation of canonical NF-kappaB signal transduction
GO:0043149
stress fiber assembly
GO:0043297
apical junction assembly
GO:0043366
beta selection
GO:0043542
endothelial cell migration
GO:0043931
ossification involved in bone maturation
GO:0044319
wound healing, spreading of cells
GO:0045198
establishment of epithelial cell apical/basal polarity
GO:0045666
positive regulation of neuron differentiation
GO:0045792
negative regulation of cell size
GO:0046638
positive regulation of alpha-beta T cell differentiation
GO:0050919
negative chemotaxis
GO:0051301
cell division
GO:0051496
positive regulation of stress fiber assembly
GO:0051893
regulation of focal adhesion assembly
GO:0060071
Wnt signaling pathway, planar cell polarity pathway
GO:0060193
positive regulation of lipase activity
GO:0061430
bone trabecula morphogenesis
GO:0070507
regulation of microtubule cytoskeleton organization
GO:0071222
cellular response to lipopolysaccharide
GO:0071345
cellular response to cytokine stimulus
GO:0071526
semaphorin-plexin signaling pathway
GO:0071803
positive regulation of podosome assembly
GO:0071902
positive regulation of protein serine/threonine kinase activity
GO:0090051
negative regulation of cell migration involved in sprouting angiogenesis
GO:0090307
mitotic spindle assembly
GO:0090324
negative regulation of oxidative phosphorylation
GO:0097049
motor neuron apoptotic process
GO:0097498
endothelial tube lumen extension
GO:0099159
regulation of modification of postsynaptic structure
GO:1901224
positive regulation of non-canonical NF-kappaB signal transduction
GO:1902766
skeletal muscle satellite cell migration
GO:1903427
negative regulation of reactive oxygen species biosynthetic process
GO:1903673
mitotic cleavage furrow formation
GO:1904695
positive regulation of vascular associated smooth muscle contraction
GO:1904996
positive regulation of leukocyte adhesion to vascular endothelial cell
GO:1905274
regulation of modification of postsynaptic actin cytoskeleton
GO:1990869
cellular response to chemokine
GO:2000177
regulation of neural precursor cell proliferation
GO:2000406
positive regulation of T cell migration
GO:2000672
negative regulation of motor neuron apoptotic process
Cellular Component
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005768
endosome
GO:0005789
endoplasmic reticulum membrane
GO:0005829
cytosol
GO:0005856
cytoskeleton
GO:0005886
plasma membrane
GO:0005925
focal adhesion
GO:0005938
cell cortex
GO:0009898
cytoplasmic side of plasma membrane
GO:0030027
lamellipodium
GO:0030054
cell junction
GO:0030425
dendrite
GO:0030496
midbody
GO:0030667
secretory granule membrane
GO:0031982
vesicle
GO:0032154
cleavage furrow
GO:0032587
ruffle membrane
GO:0042995
cell projection
GO:0043197
dendritic spine
GO:0043296
apical junction complex
GO:0070062
extracellular exosome
GO:0071944
cell periphery
GO:0098794
postsynapse
GO:0098978
glutamatergic synapse
GO:0101003
ficolin-1-rich granule membrane
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:5irc
,
PDBe:5irc
,
PDBj:5irc
PDBsum
5irc
PubMed
27481945
UniProt
P61586
|RHOA_HUMAN Transforming protein RhoA (Gene Name=RHOA)
[
Back to BioLiP
]