Structure of PDB 5iea Chain F

Receptor sequence
>5ieaF (length=118) Species: 9544,262724 [Search protein sequence]
DHCARHGEKLLLFCQEDSKVICWLCERSQEHRGHHTFLMEEVAQEYHVKL
QTALEMLRQKQQEAETERNQVAALIARGKALGEQTQYMRELISELEHRLQ
GSMMDLLQGVDGIIKRIE
3D structure
PDB5iea Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5 alpha.
ChainF
Resolution3.258 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) K221
Catalytic site (residue number reindexed from 1) K115
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
6.1.1.11: serine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F C108 D111 H125 H128 C14 D17 H31 H34
BS02 ZN F C97 H100 C3 H6
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5iea, PDBe:5iea, PDBj:5iea
PDBsum5iea
PubMed27253059
UniProtP34945|SYS_THET2 Serine--tRNA ligase (Gene Name=serS);
Q0PF16|TRIM5_MACMU Tripartite motif-containing protein 5 (Gene Name=TRIM5)

[Back to BioLiP]