Structure of PDB 5fph Chain F

Receptor sequence
>5fphF (length=394) Species: 10090 (Mus musculus) [Search protein sequence]
NNDLPSSFTGYFKKFNTGEEIISQEILNLIELRMRKGNIQLTNSAISDAL
KEIDSSVLNVAVTGETGSGKSSFINTLRGIGNEEEGAAKTGVVTMERHPY
KHPNIPNVVFWDLPGIGSTNFPPNTYLEKMKFYEYDFFIIISATRFKKND
IDIAKAISMMKEEFYFVRTKVDSDITNEADGTFDKEKVLQDIRLNCVNTF
RENGIAEPPIFLLSNKNVCHYDFPVLMDELISDLPIYKRHNFMVSLPNIT
DSVIEKKRQFLKQRIWLEGFAADLVNIIPSLTFLLDSDLETLKKSMKFYR
TVFGVDETSLQRLARDWEIEVDQVEAMIKSPAVFKPTDTIQERLSRYIQE
FCLANGYLLPKNSFLKEIFYLKYYFLDMVTEDAKTLLKEICLRN
3D structure
PDB5fph The Immunity-Related Gtpase Irga6 Dimerizes in a Parallel Head-to-Head Fashion.
ChainF
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP F G79 S80 G81 K82 S83 S84 T102 K184 D186 S187 S231 N232 K233 G67 S68 G69 K70 S71 S72 T90 K170 D172 S173 S214 N215 K216
BS02 MG F S83 D126 S71 D112
BS03 MG F D150 E176 E177 D136 E162 E163
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019003 GDP binding
GO:0042802 identical protein binding
Biological Process
GO:0009617 response to bacterium
GO:0010506 regulation of autophagy
GO:0019221 cytokine-mediated signaling pathway
GO:0035458 cellular response to interferon-beta
GO:0042832 defense response to protozoan
GO:0045087 innate immune response
GO:0050829 defense response to Gram-negative bacterium
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0020005 symbiont-containing vacuole membrane
GO:0031965 nuclear membrane
GO:0032580 Golgi cisterna membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5fph, PDBe:5fph, PDBj:5fph
PDBsum5fph
PubMed26934976
UniProtQ9QZ85|IIGP1_MOUSE Interferon-inducible GTPase 1 (Gene Name=Iigp1)

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