Structure of PDB 5ey8 Chain F

Receptor sequence
>5ey8F (length=606) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
PFIKDGQIKFPDGSSIVAHVERWAKVRGDKLAYRFLDFSTERDGVPRDLT
WAQFSARNRAVAARLQQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAV
PLFDPSEPGHVGRLHAVLDNCHPSAILTTTEAAEGVRKFFRTRPANQRPR
VIAVDAVPDDVASTWVNPDEPDETTIAYLQYTSRIPTGVQITHLNLATNV
VQVIEALEGEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVR
RPERWIRELARKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVK
AVLNGSEPISAATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSA
EEPKIITVDRDQLNSGRIVEVDADSPKAVAQASAGKVGIAEWAVIVDAES
ATELPDGQVGEIWISGQNMGTGYWGKPEESVATFQNILKSRTNPSHAEGA
TDDATWVRTGDYGAFYDGDLYITGRVKDLVIIDGRNHYPQDLEYSAQEAS
KAIRTGYVAAFSVPANQLPDEVFENAHSGIKRDPDDTSEQLVIVAERAPD
IGPITDDIRAAIAVRHGVTVRDVLLTAAGAIPRTSSGKIGRRACRAAYLD
GSLRAG
3D structure
PDB5ey8 Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria.
ChainF
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) N207 H231 A346
Catalytic site (residue number reindexed from 1) N199 H223 A338
Enzyme Commision number 6.2.1.20: long-chain-fatty-acid--[acyl-carrier-protein] ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5SV F H231 D232 S314 E315 P316 S342 Y343 G344 L345 L350 D469 H223 D224 S306 E307 P308 S334 Y335 G336 L337 L342 D461
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008922 long-chain fatty acid [acyl-carrier-protein] ligase activity
GO:0016874 ligase activity
GO:0070566 adenylyltransferase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008610 lipid biosynthetic process
Cellular Component
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5ey8, PDBe:5ey8, PDBj:5ey8
PDBsum5ey8
PubMed26900152
UniProtA0R618|FAA32_MYCS2 Long-chain-fatty-acid--AMP ligase FadD32 (Gene Name=fadD32)

[Back to BioLiP]