Structure of PDB 5dst Chain F

Receptor sequence
>5dstF (length=317) Species: 9606 (Homo sapiens) [Search protein sequence]
DSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSM
FAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVE
KVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIE
DRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKE
VDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTA
PDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLD
FKGQLCETSVSNDYKMR
3D structure
PDB5dst Novel helical assembly in arginine methyltransferase 8
ChainF
Resolution2.963 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D92 E185 E194 H334
Catalytic site (residue number reindexed from 1) D15 E108 E117 H257
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH F Y80 M89 R95 G119 I124 L125 E141 C142 K168 V169 E185 M196 T199 Y3 M12 R18 G42 I47 L48 E64 C65 K91 V92 E108 M119 T122
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5dst, PDBe:5dst, PDBj:5dst
PDBsum5dst
PubMed26876602
UniProtQ9NR22|ANM8_HUMAN Protein arginine N-methyltransferase 8 (Gene Name=PRMT8)

[Back to BioLiP]