Structure of PDB 5cbx Chain F

Receptor sequence
>5cbxF (length=74) Species: 32644 (unidentified) [Search protein sequence]
PPKICLVCGDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIID
KIRRKNCPACRFRKCLQAGMNLEA
3D structure
PDB5cbx Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
ChainF
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna F S440 R447 R470 K471 R477 S24 R31 R54 K55 R61 PDBbind-CN: Kd=0.11uM
BS02 dna F C431 H432 Y433 K442 K446 C15 H16 Y17 K26 K30 PDBbind-CN: Kd=0.11uM
BS03 ZN F C421 C424 C438 C441 C5 C8 C22 C25
BS04 ZN F C457 C463 C473 C476 C41 C47 C57 C60
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5cbx, PDBe:5cbx, PDBj:5cbx
PDBsum5cbx
PubMed26715749
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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