Structure of PDB 5c8w Chain F

Receptor sequence
>5c8wF (length=118) Species: 9606 (Homo sapiens) [Search protein sequence]
KDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGE
PGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAIT
NVKTWALDREVFQNIMRR
3D structure
PDB5c8w Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.
ChainF
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PCG F V215 S223 F231 G232 E233 L234 A235 R242 T243 V246 V65 S73 F81 G82 E83 L84 A85 R92 T93 V96 MOAD: Kd=43.8nM
External links
PDB RCSB:5c8w, PDBe:5c8w, PDBj:5c8w
PDBsum5c8w
PubMed26769964
UniProtQ13237|KGP2_HUMAN cGMP-dependent protein kinase 2 (Gene Name=PRKG2)

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