Structure of PDB 4zy2 Chain F

Receptor sequence
>4zy2F (length=512) Species: 186763 (Plasmodium falciparum FcB1/Columbia) [Search protein sequence]
SEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNP
KENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVA
VGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFR
FFLETLFYEYMTDERFKSTDEYIKHLGVYINNADTYKEEVEKARVYYFGT
YYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAY
LSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGS
MIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRP
GDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAM
LYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKY
ADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGF
GVRLLTEFVLND
3D structure
PDB4zy2 Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.
ChainF
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K386 R463
Catalytic site (residue number reindexed from 1) K295 R372
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F K374 D379 D399 E461 K283 D288 D308 E370
BS02 CO3 F A460 G462 R463 L487 A369 G371 R372 L396
BS03 ZN F D379 D459 E461 D288 D368 E370
BS04 4TL F K374 D379 M392 D459 E461 L487 T488 G489 L492 A577 F583 K283 D288 M301 D368 E370 L396 T397 G398 L401 A486 F492 MOAD: Ki=0.06uM
PDBbind-CN: -logKd/Ki=7.22,Ki=0.060uM
Gene Ontology
Molecular Function
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zy2, PDBe:4zy2, PDBj:4zy2
PDBsum4zy2
PubMed26807544
UniProtA0A0L7M119

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