Structure of PDB 4zgx Chain F |
>4zgxF (length=464) Species: 9606 (Homo sapiens) [Search protein sequence] |
TVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL GPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNG PEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSL TLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKST VQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQ HYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNP DVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLER VVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDINFH HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFIL RPGTSPLLTFRAIN |
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PDB | 4zgx Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys. |
Chain | F |
Resolution | 3.2 Å |
3D structure |
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Catalytic site (original residue number in PDB) |
T318 F443 C450 |
Catalytic site (residue number reindexed from 1) |
T284 F404 C411 |
Enzyme Commision number |
1.14.15.4: steroid 11beta-monooxygenase. 1.14.15.5: corticosterone 18-monooxygenase. |
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