Structure of PDB 4zcs Chain F

Receptor sequence
>4zcsF (length=141) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
NVVIYADGVYDMLHLGHMKQLEQAKKLFENTTLIVGVTSDNETKLFKGQV
VQTLEERTETLKHIRWVDEIISPCPWVVTPEFLEKYKIDYVAHDDIPYAN
NQKEDIYAWLKRAGKFKATQRTEGVSTTDLIVRILKNYEDY
3D structure
PDB4zcs Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis.
ChainF
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F662 G664
Catalytic site (residue number reindexed from 1) F46 G48
Enzyme Commision number 2.7.7.15: choline-phosphate cytidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CDC F D623 G624 V625 Y626 G632 H633 Q636 T654 K663 W692 H709 D710 Y714 Y741 R755 T756 D7 G8 V9 Y10 G16 H17 Q20 T38 K47 W76 H93 D94 Y98 Y107 R121 T122
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004105 choline-phosphate cytidylyltransferase activity
Biological Process
GO:0006657 CDP-choline pathway
GO:0009058 biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4zcs, PDBe:4zcs, PDBj:4zcs
PDBsum4zcs
PubMed30046154
UniProtQ8IEE9

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