Structure of PDB 4yjl Chain F

Receptor sequence

>4yjlF (length=339) Species: 9606 (Homo sapiens) [Search protein sequence]

HHHHHHMLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPA
VCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRR
YAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLR
NLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHC
TENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATN
EDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALW
DMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYK

3D structure

PDB

4yjl Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	F	E574 E578 D610	E175 E179 D211
BS02	peptide	F	F458 R463 M503 T506 N507 F510 G511 K516 D539 Q542 V543 R549 N550 W553 S583 S590 W593 N594 A597 K603 R640 N641 W685 N686	F59 R64 M104 T107 N108 F111 G112 K117 D140 Q143 V144 R150 N151 W154 S184 S191 W194 N195 A198 K204 R241 N242 W286 N287

Gene Ontology

	Molecular Function
GO:0008013	beta-catenin binding

	Biological Process
GO:0030178	negative regulation of Wnt signaling pathway

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Molecular Function

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Biological Process

External links

PDB	RCSB:4yjl, PDBe:4yjl, PDBj:4yjl
PDBsum	4yjl
PubMed	27462415
UniProt	P25054\|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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