Structure of PDB 4yha Chain F

Receptor sequence
>4yhaF (length=215) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
WDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKY
AASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNK
TRPLSAHFVHKDAKGRLLVLAIGFEEENPNLDPILEGIQKKDAFLPKSIN
YYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQ
PDYNTVIIKSSAETR
3D structure
PDB4yha Structural Basis for the Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase by Sulfonamides.
ChainF
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H85 H110 H112 E116 H129 T191
Catalytic site (residue number reindexed from 1) H63 H88 H90 E94 H107 T159
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F H110 H112 H129 H88 H90 H107
BS02 MZM F D107 N108 H110 H112 V131 T191 D85 N86 H88 H90 V109 T159 MOAD: Ki=225nM
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4yha, PDBe:4yha, PDBj:4yha
PDBsum4yha
PubMed26010545
UniProtA0A0M3KL20

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