Structure of PDB 4p3w Chain F

Receptor sequence

>4p3wF (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]

HCLSLKIMTAQVTSPSGKTHEAEIHTYCIRFVPAEMGTHTVSVKYKGQHV
PGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGL
AIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPF
VVPVASP

3D structure

PDB

4p3w Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	F	G2223 S2224 P2225 F2226 Q2227 T2229 E2313 H2315	G52 S53 P54 F55 Q56 T58 E142 H144
BS02	peptide	F	M2207 G2208 A2268 G2269 G2270 L2271 A2272 I2273 A2274 V2275 E2276 G2277 P2278 K2280 A2281 F2285	M36 G37 A97 G98 G99 L100 A101 I102 A103 V104 E105 G106 P107 K109 A110 F114

Gene Ontology

	Molecular Function
GO:0051015	actin filament binding

	Biological Process
GO:0030036	actin cytoskeleton organization

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4p3w, PDBe:4p3w, PDBj:4p3w
PDBsum	4p3w
PubMed
UniProt	P21333\|FLNA_HUMAN Filamin-A (Gene Name=FLNA)

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