Structure of PDB 4nb4 Chain F

Receptor sequence
>4nb4F (length=262) Species: 282458 (Staphylococcus aureus subsp. aureus MRSA252) [Search protein sequence]
MKVGIDAGGTLIKIVQEQDNQRTFKTELTKNIDQVVEWLNQQQLCLTGGN
AGVIAENINIPAQIFVEFDAASQGLGILLKEQGHDLADYIFANVGTGTSL
HYFDGQSQRRVGGIGTGGGMIQGLGYLLSQITDYKQLTDMAQHGDRNTID
LKVRHIYKDTEPPIPGDLTAANFGHVLHHLDADFTPSNKLAAVIGVVGEV
VTTMAITVAREFKTENIVYIGSSFHNNALLRKVVEDYTVLRGCKPYYVEN
GAFSGAIGALYL
3D structure
PDB4nb4 Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus.
ChainF
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP F G8 G9 L11 K13 G98 T99 G121 G122 Q125 Y137 G224 S225 H228 G8 G9 L11 K13 G95 T96 G118 G119 Q122 Y134 G221 S222 H225
BS02 SH3 F T172 A173 E202 Y240 T169 A170 E199 Y237
BS03 SH3 F E70 G100 T101 S102 R113 G116 I117 E67 G97 T98 S99 R110 G113 I114
BS04 MG F D6 E70 D6 E67
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4nb4, PDBe:4nb4, PDBj:4nb4
PDBsum4nb4
PubMed24470271
UniProtQ6G7I0|COAW_STAAS Type II pantothenate kinase (Gene Name=coaW)

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