Structure of PDB 4n1z Chain F

Receptor sequence
>4n1zF (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
VYAQEKQDFVQHFSQIVRVLTHPEIGDAIARLKEVLEYNAIGGKYNRGLT
VVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRR
GQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQS
SYQTEIGQTLDLLTAPQGNLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMY
MAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDN
KCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFL
QYEEDSYSHIMALIEQYAAPLPPAVFLGLARKI
3D structure
PDB4n1z A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin.
ChainF
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.1: dimethylallyltranstransferase.
2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 F R60 F239 K257 R47 F224 K242
BS02 MG F D103 D107 D90 D94
BS03 MG F D103 D107 D90 D94
BS04 PO4 F G56 K57 R60 R113 G43 K44 R47 R100
BS05 N1Z F F99 D103 D107 R112 Q171 K200 D243 K257 F86 D90 D94 R99 Q158 K185 D228 K242 PDBbind-CN: -logKd/Ki=9.14,Ki=0.72nM
Gene Ontology
Molecular Function
GO:0004659 prenyltransferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process
GO:0008299 isoprenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4n1z, PDBe:4n1z, PDBj:4n1z
PDBsum4n1z
PubMed25411474
UniProtP14324|FPPS_HUMAN Farnesyl pyrophosphate synthase (Gene Name=FDPS)

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