Structure of PDB 4mvd Chain F

Receptor sequence
>4mvdF (length=253) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GLRQPAPFSDEIEVDFSKPYVRVTMEEACRGTPCERPVRVYADGIFDLFH
SGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHC
RYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAG
MFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKK
YHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLWEEKSREFIGSFLEM
FGP
3D structure
PDB4mvd Structural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic Helix.
ChainF
Resolution8.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F121 G123
Catalytic site (residue number reindexed from 1) F82 G84
Enzyme Commision number 2.7.7.15: choline-phosphate cytidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CDC F D82 G83 I84 A95 R196 D43 G44 I45 A56 R157
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004105 choline-phosphate cytidylyltransferase activity
Biological Process
GO:0006657 CDP-choline pathway
GO:0009058 biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4mvd, PDBe:4mvd, PDBj:4mvd
PDBsum4mvd
PubMed24275660
UniProtP19836|PCY1A_RAT Choline-phosphate cytidylyltransferase A (Gene Name=Pcyt1a)

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