Structure of PDB 4kxf Chain F

Receptor sequence
>4kxfF (length=899) Species: 10090 (Mus musculus) [Search protein sequence]
EEDLNVLAQNLKDLYNSPAFLNFYPLGEDIDIIFNLEKTFTEPIMWKKDH
RHHRVEQLTLGSLLEALKSPCLIEGESGKGKSTLLQRIAMLWASGGCRAL
KGFRLVFFIHLRSARGGLFETLYDQLLNIPDFISKPTFKALLLKLHKEVL
FLLDGYNEFHPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRHVGALT
AEVGDMTEDSAKDLIEAVLVPDQVERLWAQIQESRCLRNLMKTPLFVVIT
CAIQMGRQEFQAHTQTMLFQTFYDLLIQKNSHRYRGGASGDFARSLDYCG
DLALEGVFAHKFDFEPEHGSSMNEDVLVTIGLLCKYTAQRLKPTYKFFHK
SFQEYTAGRRLSSLLTSKEPEEVSKGNSYLNKMVSISDITSLYGNLLLYT
CGSSTEATRAVMRHLAMVYQHGSLQGLSVTESIQSLRNTTEQDVLKAINV
NSFVECGINLFSESMSKSDLSQEFEAFFQGKSLYINSENIPDYLFDFFEY
LPNCASALDFVKLDFYERATPPRAVSLFFNWKQEFKTLEVTLRDINKLNK
QDIKYLGKIFSSATNLRLHIKRCAAMAGRLSSVLRTCKNMHTLMVEASPL
TTDDEQYITSVTGLQNLSIHRLHTQQLPGGLIDSLGNLKNLERLILDDIR
MNEEDAKNLAEGLRSLKKMRLLHLTHLSDIGEGMDYIVKSLSEESCDLQE
MKLVACCLTANSVKVLAQNLHNLIKLSILDISENYLEKDGNEALQELIGR
LGVLGELTTLMLPWCWDVHTSLPKLLKQLEGTPGLAKLGLKNWRLRDEEI
KSLGEFLEMNPLRDLQQLDLAGHCVSSDGWLYFMNVFENLKQLVFFDFST
EEFLPDAALVRKLSQVLSKLTLLQEVKLTGWEFDDYDISAIKGTFKLVT
3D structure
PDB4kxf Crystal structure of NLRC4 reveals its autoinhibition mechanism
ChainF
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP F P119 F128 F134 T135 G172 K173 G174 K175 S176 T177 P338 L339 H443 P25 F34 F40 T41 G78 K79 G80 K81 S82 T83 P244 L245 H349
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0002218 activation of innate immune response
GO:0006915 apoptotic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0016045 detection of bacterium
GO:0032731 positive regulation of interleukin-1 beta production
GO:0042742 defense response to bacterium
GO:0042981 regulation of apoptotic process
GO:0045087 innate immune response
GO:0051260 protein homooligomerization
GO:0070269 pyroptotic inflammatory response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0061702 canonical inflammasome complex
GO:0072557 IPAF inflammasome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4kxf, PDBe:4kxf, PDBj:4kxf
PDBsum4kxf
PubMed23765277
UniProtQ3UP24|NLRC4_MOUSE NLR family CARD domain-containing protein 4 (Gene Name=Nlrc4)

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