Structure of PDB 4ic1 Chain F

Receptor sequence
>4ic1F (length=203) Species: 273057 (Saccharolobus solfataricus P2) [Search protein sequence]
YFQGMITEFLLKKKLEEHLSHVKEENTIYVTDLVRCPRRVRYESEYKELA
ISQVYAPSAILGDILHLGLESVLKGNFNAETEVETLREINVGGKVYKIKG
RADAIIRNKSIVIEIKTSRSDKGLPLIHHKMQLQIYLWLFSAEKGILVYI
TPDRIAEYEINEPLDEATIVRLAEDTIMLQNSPRFNWECKYCIFSVICPA
KLT
3D structure
PDB4ic1 Toroidal structure and DNA cleavage by the CRISPR-associated [4Fe-4S] cluster containing Cas4 nuclease SSO0001 from Sulfolobus solfataricus.
ChainF
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.12.1: 5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN F H62 D99 E113 I114 K115 H66 D103 E114 I115 K116
BS02 SF4 F C32 R35 C188 C191 C197 C36 R39 C189 C192 C198
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004527 exonuclease activity
GO:0030145 manganese ion binding
GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006308 DNA catabolic process
GO:0032508 DNA duplex unwinding
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:4ic1, PDBe:4ic1, PDBj:4ic1
PDBsum4ic1
PubMed24171432
UniProtQ97TX9|CAS4_SACS2 CRISPR-associated exonuclease Cas4 (Gene Name=cas4)

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