Structure of PDB 4hz5 Chain F

Receptor sequence
>4hz5F (length=191) Species: 226185 (Enterococcus faecalis V583) [Search protein sequence]
GLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNAVDEALSGYGNEINVTIQK
DNSICVADSGRGMPTGMHASGIPTVEVIFTVLHHGVGASVVNALSKWLEV
HIVRDGVEYMERFEDGGKPVGTLKKIGKTKKRNGTSVTFLPDDTIFSTTN
FSYEILAERLRESAFLLKGVKITLTDERGEEPKEEVFHYEE
3D structure
PDB4hz5 Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
ChainF
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 19Y F I46 N49 E53 D76 R79 G80 M81 P82 T169 I28 N31 E35 D58 R61 G62 M63 P64 T135
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4hz5, PDBe:4hz5, PDBj:4hz5
PDBsum4hz5
PubMed23352267
UniProtH7C794|PARE_ENTFA DNA topoisomerase 4 subunit B (Gene Name=parE)

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