Structure of PDB 4fp9 Chain F

Receptor sequence
>4fp9F (length=338) Species: 9606 (Homo sapiens) [Search protein sequence]
PAVRLALQNFDMTYSVQFGDLWPSIRVSLLSEQKYGALVNNFAAWDHVSA
KLEQLSAKDFVNEAISHWELQPSPASWACSPNLRCFTFDRGDISRFPPAR
PGSLGVMEYYLMDAASLLPVLALGLQPGDIVLDLCAAPGGKTLALLQTGC
CRNLAANDLSPSRIARLQKILHSYVPEEIRDGNQVRVTSWDGRKWGELEG
DTYDRVLVDVPCTTDRHSLHEEENNIFKRSRKKERQILPVLQVQLLAAGL
LATKPGGHVVYSTCSLSHLQNEYVVQGAIELLANQYSIQVQVEDLTHFRR
VFMDTFCFFSSCQVGELVIPNLMANFGPMYFCKMRRLT
3D structure
PDB4fp9 Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis.
ChainF
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM F C181 A182 A183 P184 G186 K187 D204 L205 R209 D237 G238 D255 P257 L291 C135 A136 A137 P138 G140 K141 D158 L159 R163 D191 G192 D209 P211 L245
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0008649 rRNA methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity
GO:0016428 tRNA (cytidine-5-)-methyltransferase activity
GO:0019843 rRNA binding
Biological Process
GO:0001510 RNA methylation
GO:0006364 rRNA processing
GO:0031167 rRNA methylation
GO:0032259 methylation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005762 mitochondrial large ribosomal subunit

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4fp9, PDBe:4fp9, PDBj:4fp9
PDBsum4fp9
PubMed22949673
UniProtQ96CB9|NSUN4_HUMAN 5-methylcytosine rRNA methyltransferase NSUN4 (Gene Name=NSUN4)

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