Structure of PDB 4fmd Chain F

Receptor sequence
>4fmdF (length=149) Species: 9606 (Homo sapiens) [Search protein sequence]
KLLLIGDSGVGKSCLLLRFADDTYTISTIGVDFKIRIWDTAGQERFRTIT
SSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGNKCD
LTTKKVVDYTTAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRM
3D structure
PDB4fmd Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses.
ChainF
Resolution3.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q70
Catalytic site (residue number reindexed from 1) Q43
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AF3 F S20 G21 T43 G69 S8 G9 T28 G42
BS02 GDP F G21 G23 K24 S25 C26 Y36 K125 D127 A155 K156 G9 G11 K12 S13 C14 Y24 K98 D100 A128 K129
BS03 MG F S25 T43 S13 T28
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4fmd, PDBe:4fmd, PDBj:4fmd
PDBsum4fmd
PubMed22939626
UniProtP62820|RAB1A_HUMAN Ras-related protein Rab-1A (Gene Name=RAB1A)

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