Structure of PDB 4fmc Chain F

Receptor sequence
>4fmcF (length=73) Species: 9606 (Homo sapiens) [Search protein sequence]
LLLIGDSGVGKSCLLLRFADYTYISTIGVDFQIWDTAGQERFRTISSDVT
DESFNNVKQWLQEIDRYASELTT
3D structure
PDB4fmc Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses.
ChainF
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q70
Catalytic site (residue number reindexed from 1) Q39
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AF3 F S20 G21 T43 S7 G8 T26
BS02 GDP F G21 V22 G23 K24 S25 G8 V9 G10 K11 S12
BS03 MG F S25 T43 D66 S12 T26 D35
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4fmc, PDBe:4fmc, PDBj:4fmc
PDBsum4fmc
PubMed22939626
UniProtP62820|RAB1A_HUMAN Ras-related protein Rab-1A (Gene Name=RAB1A)

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