Structure of PDB 4f86 Chain F

Receptor sequence
>4f86F (length=269) Species: 324833 (Streptomyces lasalocidi) [Search protein sequence]
TPYQEDIARYWNNRPVNLRLGDVDGLYHHHYGIGAVDHAALGDGGYEARL
IAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRFGCKV
EGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAASWNNE
SSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQINAHFE
CNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGIEEAF
IESYRDGSFQYVLIAADRV
3D structure
PDB4f86 Structure analysis of geranyl pyrophosphate methyltransferase and the proposed reaction mechanism of SAM-dependent C-methylation
ChainF
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.255: geranyl diphosphate 2-C-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG F W37 H57 H58 G113 C114 T135 L136 Q140 C162 N163 M164 N180 E181 S182 Y185 W11 H29 H30 G82 C83 T104 L105 Q109 C131 N132 M133 N149 E150 S151 Y154
BS02 GPP F W37 R42 N45 H57 Y59 M184 G210 I234 R268 F281 W11 R14 N17 H29 Y31 M153 G179 I203 R237 F250
BS03 MG F N45 E89 N17 E58
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008168 methyltransferase activity
GO:0008169 C-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:1904047 S-adenosyl-L-methionine binding
Biological Process
GO:0032259 methylation
GO:0042214 terpene metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4f86, PDBe:4f86, PDBj:4f86
PDBsum4f86
PubMed23090405
UniProtD3KYU3|GPPMT_STRLS Geranyl diphosphate 2-C-methyltransferase (Gene Name=gdpmt)

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