Structure of PDB 4e5p Chain F

Receptor sequence
>4e5pF (length=328) Species: 316 (Stutzerimonas stutzeri) [Search protein sequence]
MLPKLVITHRVHEEILQLLAPHCELITNQTDSTLTREEILRRCRDAQAMM
AFMPDRVDADFLQACPELRVIGCALKGFDNFDVDACTARGVWLTFVPDLL
TVPTAELAIGLAVGLGRHLRAADAFVRSGQFRGWQPRFYGTGLDNATVGF
LGMGAIGLAMADRLQGWGATLQYHARKALDTQTEQRLGLRQVACSELFAS
SDFILLALPLNADTLHLVNAELLALVRPGALLVNPCRGSVVDEAAVLAAL
ERGQLGGYAADVFEMEDWARADRPQQIDPALLAHPNTLFTPHIGSAVRAV
RLEIERCAAQNILQALAGERPINAVNRL
3D structure
PDB4e5p Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration.
ChainF
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L100 R237 D261 E266 H292
Catalytic site (residue number reindexed from 1) L100 R237 D261 E266 H292
Enzyme Commision number 1.20.1.1: phosphonate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD F T104 M153 G154 A155 I156 A175 R176 A207 L208 P209 P235 C236 R237 H292 T104 M153 G154 A155 I156 A175 R176 A207 L208 P209 P235 C236 R237 H292
Gene Ontology
Molecular Function
GO:0008465 hydroxypyruvate reductase (NADH) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030267 glyoxylate reductase (NADPH) activity
GO:0050609 phosphonate dehydrogenase activity
GO:0051287 NAD binding
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:4e5p, PDBe:4e5p, PDBj:4e5p
PDBsum4e5p
PubMed22564171
UniProtO69054|PTXD_STUST Phosphonate dehydrogenase (Gene Name=ptxD)

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