Structure of PDB 4dy7 Chain F

Receptor sequence
>4dy7F (length=378) Species: 9606 (Homo sapiens) [Search protein sequence]
HFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGAD
GRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNAS
EIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLS
PDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPML
AQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIP
HISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSS
KANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPW
FIVDRPFLFFIRHNPTGAVLFMGQINKP
3D structure
PDB4dy7 Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
ChainF
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 CA F T309 T310 G311 T308 T309 G310
Gene Ontology
Molecular Function
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
Biological Process
GO:0007399 nervous system development
GO:0007596 blood coagulation
GO:0008285 negative regulation of cell population proliferation
GO:0009611 response to wounding
GO:0010466 negative regulation of peptidase activity
GO:0010544 negative regulation of platelet activation
GO:0010757 negative regulation of plasminogen activation
GO:0010766 negative regulation of sodium ion transport
GO:0010955 negative regulation of protein processing
GO:0021683 cerebellar granular layer morphogenesis
GO:0030154 cell differentiation
GO:0030163 protein catabolic process
GO:0030168 platelet activation
GO:0030195 negative regulation of blood coagulation
GO:0030308 negative regulation of cell growth
GO:0030334 regulation of cell migration
GO:0032940 secretion by cell
GO:0033363 secretory granule organization
GO:0042177 negative regulation of protein catabolic process
GO:0042628 mating plug formation
GO:0045861 negative regulation of proteolysis
GO:0045879 negative regulation of smoothened signaling pathway
GO:0048505 regulation of timing of cell differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0050974 detection of mechanical stimulus involved in sensory perception
GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060291 long-term synaptic potentiation
GO:0060384 innervation
GO:0061108 seminal vesicle epithelium development
GO:0090331 negative regulation of platelet aggregation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0031091 platelet alpha granule
GO:0031594 neuromuscular junction
GO:0062023 collagen-containing extracellular matrix
GO:1903561 extracellular vesicle

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:4dy7, PDBe:4dy7, PDBj:4dy7
PDBsum4dy7
PubMed22618708
UniProtP07093|GDN_HUMAN Glia-derived nexin (Gene Name=SERPINE2)

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