Structure of PDB 4dy7 Chain F
Receptor sequence
>4dy7F (length=378) Species:
9606
(Homo sapiens) [
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HFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGAD
GRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNAS
EIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLS
PDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPML
AQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIP
HISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSS
KANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPW
FIVDRPFLFFIRHNPTGAVLFMGQINKP
3D structure
PDB
4dy7
Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Chain
F
Resolution
2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number
?
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
CA
F
T309 T310 G311
T308 T309 G310
Gene Ontology
Molecular Function
GO:0004867
serine-type endopeptidase inhibitor activity
GO:0005102
signaling receptor binding
GO:0005515
protein binding
GO:0005539
glycosaminoglycan binding
GO:0008201
heparin binding
Biological Process
GO:0007399
nervous system development
GO:0007596
blood coagulation
GO:0008285
negative regulation of cell population proliferation
GO:0009611
response to wounding
GO:0010466
negative regulation of peptidase activity
GO:0010544
negative regulation of platelet activation
GO:0010757
negative regulation of plasminogen activation
GO:0010766
negative regulation of sodium ion transport
GO:0010955
negative regulation of protein processing
GO:0021683
cerebellar granular layer morphogenesis
GO:0030154
cell differentiation
GO:0030163
protein catabolic process
GO:0030168
platelet activation
GO:0030195
negative regulation of blood coagulation
GO:0030308
negative regulation of cell growth
GO:0030334
regulation of cell migration
GO:0032940
secretion by cell
GO:0033363
secretory granule organization
GO:0042177
negative regulation of protein catabolic process
GO:0042628
mating plug formation
GO:0045861
negative regulation of proteolysis
GO:0045879
negative regulation of smoothened signaling pathway
GO:0048505
regulation of timing of cell differentiation
GO:0048711
positive regulation of astrocyte differentiation
GO:0050974
detection of mechanical stimulus involved in sensory perception
GO:0051898
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0051966
regulation of synaptic transmission, glutamatergic
GO:0060291
long-term synaptic potentiation
GO:0060384
innervation
GO:0061108
seminal vesicle epithelium development
GO:0090331
negative regulation of platelet aggregation
Cellular Component
GO:0005576
extracellular region
GO:0005615
extracellular space
GO:0005829
cytosol
GO:0031091
platelet alpha granule
GO:0031594
neuromuscular junction
GO:0062023
collagen-containing extracellular matrix
GO:1903561
extracellular vesicle
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:4dy7
,
PDBe:4dy7
,
PDBj:4dy7
PDBsum
4dy7
PubMed
22618708
UniProt
P07093
|GDN_HUMAN Glia-derived nexin (Gene Name=SERPINE2)
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