Structure of PDB 4d11 Chain F

Receptor sequence
>4d11F (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
VRWPDFNQEAYPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLP
ATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGAL
LGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEP
LLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMT
PEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENL
EISFRVWQCGGSLEIIPCSRVGHVFR
3D structure
PDB4d11 Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N- Acetylgalactosaminyltransferase 2.
ChainF
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN F D224 H226 H359 D138 H140 H273
BS02 UDP F T143 F144 R201 D224 S225 H226 R362 T57 F58 R115 D138 S139 H140 R276
Gene Ontology
Molecular Function
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0030145 manganese ion binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0016266 O-glycan processing
GO:0018242 protein O-linked glycosylation via serine
GO:0018243 protein O-linked glycosylation via threonine
GO:0051604 protein maturation
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0016020 membrane
GO:0032580 Golgi cisterna membrane
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4d11, PDBe:4d11, PDBj:4d11
PDBsum4d11
PubMed24954443
UniProtQ10471|GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (Gene Name=GALNT2)

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