Structure of PDB 4cqm Chain F

Receptor sequence
>4cqmF (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
HHHHMDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDL
GGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTK
TEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQS
VYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFVHTDMTKDLKEEHLKK
NIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL
3D structure
PDB4cqm Insights Into Mitochondrial Fatty Acid Synthesis from the Structure of Heterotetrameric 3-Ketoacyl-Acp Reductase/3R-Hydroxyacyl-Coa Dehydrogenase.
ChainF
Resolution2.339 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G13 S135 Q145 Y148 K152
Catalytic site (residue number reindexed from 1) G17 S139 Q149 Y152 K156
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
1.6.5.10: NADPH dehydrogenase (quinone).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP F G9 R12 G13 I14 A33 R34 N35 D56 V57 A83 A84 G85 V133 S135 Y148 K152 V181 T183 M185 G13 R16 G17 I18 A37 R38 N39 D60 V61 A87 A88 G89 V137 S139 Y152 K156 V185 T187 M189 MOAD: Kd=26.8uM
Gene Ontology
Molecular Function
GO:0003955 NAD(P)H dehydrogenase (quinone) activity
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0005515 protein binding
GO:0008753 NADPH dehydrogenase (quinone) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0048038 quinone binding
GO:0070402 NADPH binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
GO:0046949 fatty-acyl-CoA biosynthetic process
GO:0051289 protein homotetramerization
GO:0051290 protein heterotetramerization
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:1990204 oxidoreductase complex

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Cellular Component
External links
PDB RCSB:4cqm, PDBe:4cqm, PDBj:4cqm
PDBsum4cqm
PubMed25203508
UniProtQ8N4T8|CBR4_HUMAN 3-oxoacyl-[acyl-carrier-protein] reductase (Gene Name=CBR4)

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