Structure of PDB 4awj Chain F

Receptor sequence
>4awjF (length=142) Species: 9606 (Homo sapiens) [Search protein sequence]
LRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSY
RGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERC
LQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQE
3D structure
PDB4awj Dissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface.
ChainF
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V6F F W88 Y98 H110 S111 Y112 H115 W117 W26 Y36 H48 S49 Y50 H53 W55 MOAD: Kd~10000uM
BindingDB: Kd=4900000nM
External links
PDB RCSB:4awj, PDBe:4awj, PDBj:4awj
PDBsum4awj
PubMed23102223
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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