Structure of PDB 3wiy Chain F

Receptor sequence
>3wiyF (length=150) Species: 9606 (Homo sapiens) [Search protein sequence]
DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
3D structure
PDB3wiy Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
ChainF
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LC6 F S255 R300 S84 R129 MOAD: ic50=0.61uM
BindingDB: IC50=610nM
BS02 LC6 F A227 F228 L235 M250 V253 F254 R263 T266 L267 F270 G271 A56 F57 L64 M79 V82 F83 R92 T95 L96 F99 G100 MOAD: ic50=0.61uM
BindingDB: IC50=610nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:3wiy, PDBe:3wiy, PDBj:3wiy
PDBsum3wiy
PubMed24215352
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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