Structure of PDB 3u9s Chain F

Receptor sequence
>3u9sF (length=537) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
SHMAILHTQINPRSAEFAANAATMLEQVNALRTLLGRIHEGGGSAAQARH
SARGKLLVRERINRLLDPGSPFLELSALAAHEVYGEEVAAAGIVAGIGRV
EGVECMIVGNDATVKGGTYYPLTVKKHLRAQAIALENRLPCIYLVDSGGA
NLPRQDEVFPDREHFGRIFFNQANMSARGIPQIAVVMGSCTAGGAYVPAM
SDETVMVREQATIFLAGPPLVKAATGEVVSAEELGGADVHCKVSGVADHY
AEDDDHALAIARRCVANLNWRKQGQLQCRAPRAPLYPAEELYGVIPADSK
QPYDVREVIARLVDGSEFDEFKALFGTTLVCGFAHLHGYPIAILANNGIL
FAEAAQKGAHFIELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLV
TAVACARVPKFTVLIGGSFGAGNYGMCGRAYDPRFLWMWPNARIGVMGGE
QAAGVLAQVKREQAERAGQQLGVEEEAKIKAPILEQYEHQGHPYYSSARL
WDDGVIDPAQTREVLALALSAALNAPIEPTAFGVFRM
3D structure
PDB3u9s An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase
ChainF
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A176 A218 G219 F407 A447 G448
Catalytic site (residue number reindexed from 1) A150 A192 G193 F381 A421 G422
Enzyme Commision number 6.4.1.4: methylcrotonoyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BTI F T405 G406 F407 A447 M473 T379 G380 F381 A421 M447
BS02 COA F R74 K141 T144 A176 N177 L178 R49 K115 T118 A150 N151 L152
Gene Ontology
Molecular Function
GO:0004485 methylcrotonoyl-CoA carboxylase activity
GO:0005515 protein binding
GO:0016874 ligase activity
Biological Process
GO:0006552 L-leucine catabolic process
GO:0008300 isoprenoid catabolic process
Cellular Component
GO:1905202 methylcrotonoyl-CoA carboxylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3u9s, PDBe:3u9s, PDBj:3u9s
PDBsum3u9s
PubMed22158123
UniProtQ9I297

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