Structure of PDB 3sxn Chain F

Receptor sequence

>3sxnF (length=402) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

MITPRTLHTITDDDWTRIALLARFAFGDIEPEQTQAAWRSMVPEDATVVV
PDETDDAFVGQSLYLDMQLTVPGGEVLPVAGISFVAVAPTHRRRGVLRAM
YTELHDRIARAGYPLAVLTASEGGIYGRFGYGVATIEQHVSVDRRLAQFH
PAAPDPGGVRMLVPADHRDGLADIYDRWRRRTPGGLVRPDALWDDLLADR
PESRRGGGELFAFGHQDGYALYRVDRGPDGRRSAHVVELTAVTADAHAAL
WRALLGLDLIDRVSIGTHPHDPLPYLLTDPRQAQVTASADDLWIRIMNVP
AALEARRYQADLDVVLDVADGFRSDGGRFALQISGGRARCTTTDAPADIE
IDLDVLGGLYLGAHRVDGFAAANRLRSKDSELLQQFGAAFAGDMPAELGY
GF

3D structure

• PDB: 3sxn Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7
• Chain: F
• Resolution: 2.03 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): L21
• Catalytic site (residue number reindexed from 1): L21

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	COA	F	F26 V85 A86 V87 R92 R93 G95 L97 R98 S121 I125 Y126 R128	F26 V85 A86 V87 R92 R93 G95 L97 R98 S121 I125 Y126 R128

Gene Ontology

Molecular Function

• GO:0008080 N-acetyltransferase activity
• GO:0016746 acyltransferase activity
• GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
• GO:0034069 aminoglycoside N-acetyltransferase activity

Biological Process

• GO:0030649 aminoglycoside antibiotic catabolic process

Cellular Component

• GO:0005576 extracellular region
• GO:0044161 host cell cytoplasmic vesicle

External links

• PDB: RCSB:3sxn, PDBe:3sxn, PDBj:3sxn
• PDBsum: 3sxn
• PubMed: 22547814
• UniProt: A0QY29