Structure of PDB 3sso Chain F

Receptor sequence
>3ssoF (length=393) Species: 28040 (Micromonospora griseorubida) [Search protein sequence]
EFDEATVQDVVRLAGGHDSELRELTQKYDPAMISRLLVAEILSRCPPPSN
DTPVLVELAIVHGSERFRHFLRVVRDSPIRPVGADEGFVGMLVEYELTEL
LRELFGVTHERPAGVRGTKLFPYLTDDEEAVEQIGTYLLAAQQGTEAVLA
GCGSRKPDLSELSSRYFTPKFGFLHWFTPHYDRHFRDYRNQQVRVLEIGV
GGYKHPEWGGGSLRMWKSFFPRGQIYGLDIMDKSHVDELRIRTIQGDQND
AEFLDRIARRYGPFDIVIDDGSHINAHVRTSFAALFPHVRPGGLYVIEDM
WTAYWPGFGGQADPQECSGTSLGLLKSLIDAIQHQELPSDPNRSPGYVDR
NIVGLHVYHNVAFVEKGRNDEGGIPTWIPRDFESLVQASSGGA
3D structure
PDB3sso A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway.
ChainF
Resolution1.895 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.238: mycinamicin VI 2''-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG F D275 E303 D304 D270 E298 D299
BS02 SAH F T173 K175 E202 G204 G206 Y208 S217 D234 I235 D252 Q253 D275 G276 T168 K170 E197 G199 G201 Y203 S212 D229 I230 D247 Q248 D270 G271
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0046872 metal ion binding
GO:0102302 mycinamicin VI 2''-O-methyltransferase activity
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0032259 methylation
GO:0051289 protein homotetramerization

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Molecular Function
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Biological Process
External links
PDB RCSB:3sso, PDBe:3sso, PDBj:3sso
PDBsum3sso
PubMed21884704
UniProtQ83WF2|MYCE_MICGR Mycinamicin VI 2''-O-methyltransferase (Gene Name=mycE)

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