Structure of PDB 3sdk Chain F

Receptor sequence
>3sdkF (length=236) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
SVFSPDGRNFQVEYAVKAVENGTTSIGIKCNDGVVFAVEKLITSKLLVPQ
KNVKIQVVDRHIGCVYSGLIPDGRHLVNRGREEAASFKKLYKTPIPIPAF
ADRLGQYVQAHTLYNSVRPFGVSTIFGGVDKNGAHLYMLEPSGSYWGYKG
AATGKGRQSAKAELEKLVDHHPEGLSAREAVKQAAKIIYLAHEDNKEKDF
ELEISWCSLSETNGLHKFVKGDLLQEAIDFAQKEIN
3D structure
PDB3sdk Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
ChainF
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T35 E51 L53 K66 G80 K167
Catalytic site (residue number reindexed from 1) T23 E39 L41 K54 G68 K155
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG F A164 T165 R169 K173 A152 T153 R157 K161
BS02 MG F S13 N127 S1 N115
Gene Ontology
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex

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Biological Process
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Cellular Component
External links
PDB RCSB:3sdk, PDBe:3sdk, PDBj:3sdk
PDBsum3sdk
PubMed20875739
UniProtP21242|PSA7_YEAST Probable proteasome subunit alpha type-7 (Gene Name=PRE10)

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