Structure of PDB 3sdi Chain F

Receptor sequence
>3sdiF (length=242) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
GYDLSNSVFSPDGRNFQVEYAVKAVENGTTSIGIKCNDGVVFAVEKLITS
KLLVPQKNVKIQVVDRHIGCVYSGLIPDGRHLVNRGREEAASFKKLYKTP
IPIPAFADRLGQYVQAHTLYNSVRPFGVSTIFGGVDKNGAHLYMLEPSGS
YWGYKGAATGKGRQSAKAELEKLVDHHPEGLSAREAVKQAAKIIYLAHED
NKEKDFELEISWCSLSETNGLHKFVKGDLLQEAIDFAQKEIN
3D structure
PDB3sdi Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
ChainF
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T35 E51 L53 K66 G80 K167
Catalytic site (residue number reindexed from 1) T29 E45 L47 K60 G74 K161
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG F S13 N127 S7 N121
Gene Ontology
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex

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Biological Process
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Cellular Component
External links
PDB RCSB:3sdi, PDBe:3sdi, PDBj:3sdi
PDBsum3sdi
PubMed20875739
UniProtP21242|PSA7_YEAST Probable proteasome subunit alpha type-7 (Gene Name=PRE10)

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