Structure of PDB 3rg2 Chain F

Receptor sequence
>3rg2F (length=604) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
SIPFTRWPEEFARRYREKGYWQDLPLTDILTRHAASDSIAVIDGERQLSY
RELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPV
LALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRV
VQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIP
RTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGG
TVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLAS
LKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKI
IHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHN
ASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLL
LRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLREQGIAEF
KLPDRVECVDSLPLTAVGKVDKKQLRQWLASRASAPASKAALREVILPLL
DESDEPFDDDNLIDYGLDSVRMMALAARWRKVHGDIDFVMLAKNPTIDAW
WKLL
3D structure
PDB3rg2 Structural and Functional Investigation of the Intermolecular Interaction between NRPS Adenylation and Carrier Protein Domains.
ChainF
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S190 S210 H234 A335 E336 N436 K441 K520
Catalytic site (residue number reindexed from 1) S189 S209 H233 A334 E335 N435 K440 K519
Enzyme Commision number 3.3.2.1: isochorismatase.
6.2.1.71: 2,3-dihydroxybenzoate--[aryl-carrier protein] ligase.
6.3.2.14: enterobactin synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SVS F N235 Y236 G309 A310 V331 F332 G333 M334 A335 D415 V427 N234 Y235 G308 A309 V330 F331 G332 M333 A334 D414 V426
BS02 PNS F P231 H234 V279 G438 G439 P230 H233 V278 G437 G438
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008668 2,3-dihydroxybenzoate--[aryl-carrier protein] ligase
GO:0016746 acyltransferase activity
GO:0016874 ligase activity
GO:0016877 ligase activity, forming carbon-sulfur bonds
GO:0047527 2,3-dihydroxybenzoate-serine ligase activity
Biological Process
GO:0009239 enterobactin biosynthetic process
GO:0019290 siderophore biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3rg2, PDBe:3rg2, PDBj:3rg2
PDBsum3rg2
PubMed22365602
UniProtP0ADI4|ENTB_ECOLI Enterobactin synthase component B (Gene Name=entB);
P10378|ENTE_ECOLI Enterobactin synthase component E (Gene Name=entE)

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