Structure of PDB 3q0j Chain F

Receptor sequence
>3q0jF (length=254) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
MTYETILVERDQRVGIITLNRPQALNALNSQVMNEVTSAATELDDDPDIG
AIIITGSAKAFAAGADIKEMADLTFADAFTADFFATWGKLAAVRTPTIAA
VAGYALGGGCELAMMCDVLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAI
GKAKAMDLILTGRTMDAAEAERSGLVSRVVPADDLLTEARATATTISQMS
ASAARMAKEAVNRAFESSLSEGLLYERRLFHSAFATEDQSEGMAAFIEKR
APQF
3D structure
PDB3q0j Crystal Structure and Mechanism of the Prokaryotic Crotonase
ChainF
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A65 M70 T80 F84 G108 E111 P130 E131 V136 P138 G139 L224 F234
Catalytic site (residue number reindexed from 1) A65 M70 T80 F84 G108 E111 P130 E131 V136 P138 G139 L224 F234
Enzyme Commision number 4.2.1.17: enoyl-CoA hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CAA F Q23 A24 A27 A63 G64 A65 D66 I67 F84 Y104 G107 G108 E111 P130 E131 M140 Q23 A24 A27 A63 G64 A65 D66 I67 F84 Y104 G107 G108 E111 P130 E131 M140
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004300 enoyl-CoA hydratase activity
GO:0016829 lyase activity
GO:0016836 hydro-lyase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
Cellular Component
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Cellular Component
External links
PDB RCSB:3q0j, PDBe:3q0j, PDBj:3q0j
PDBsum3q0j
PubMed
UniProtP9WNN9|ECHA8_MYCTU Probable enoyl-CoA hydratase EchA8 (Gene Name=echA8)

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