Structure of PDB 3oeu Chain F

Receptor sequence
>3oeuF (length=237) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
NSVFSPDGRNFQVEYAVKAVENGTTSIGIKCNDGVVFAVEKLITSKLLVP
QKNVKIQVVDRHIGCVYSGLIPDGRHLVNRGREEAASFKKLYKTPIPIPA
FADRLGQYVQAHTLYNSVRPFGVSTIFGGVDKNGAHLYMLEPSGSYWGYK
GAATGKGRQSAKAELEKLVDHHPEGLSAREAVKQAAKIIYLAHEDNKEKD
FELEISWCSLSETNGLHKFVKGDLLQEAIDFAQKEIN
3D structure
PDB3oeu Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
ChainF
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) T35 E51 L53 K66 G80 K167
Catalytic site (residue number reindexed from 1) T24 E40 L42 K55 G69 K156
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG F M150 T165 M139 T154
Gene Ontology
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3oeu, PDBe:3oeu, PDBj:3oeu
PDBsum3oeu
PubMed20875739
UniProtP21242|PSA7_YEAST Probable proteasome subunit alpha type-7 (Gene Name=PRE10)

[Back to BioLiP]