Structure of PDB 3ny2 Chain F

Receptor sequence
>3ny2F (length=72) Species: 9606 (Homo sapiens) [Search protein sequence]
GSLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGG
GGFCDCGDTEAWKEGPYCQKHE
3D structure
PDB3ny2 Structural basis of substrate recognition and specificity in the N-end rule pathway.
ChainF
Resolution2.61 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN F C99 C127 C149 C4 C32 C54
BS02 ZN F C127 C151 H166 C32 C56 H71
BS03 ZN F C112 C115 H133 H136 C17 C20 H38 H41
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3ny2, PDBe:3ny2, PDBj:3ny2
PDBsum3ny2
PubMed20835242
UniProtQ8IWV8|UBR2_HUMAN E3 ubiquitin-protein ligase UBR2 (Gene Name=UBR2)

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